SAMe (pronounced “Sammy”) is a form of the amino acid methionine that occurs naturally in the body and is used for many essential functions, such as making cartilage. SAMe appears to increase the levels of certain neurotransmitters, and may thereby affect moods and emotions. In nine studies, SAMe compared favor- ably with antidepressant drugs, including imipramine, amitriptyline, and clomipramine. Some researchers have found that SAMe supplementation has improved mood disorders without the side effects of other antidepressants (such as weight gain, headaches, sleep disturbances, and sexual dysfunction). And SAMe works faster than some prescription antidepressants, often in four to ten days compared with two to six weeks for such drugs. However, when it comes to taking SAMe as a relief from psychological problems, never attempt to self-medicate— always consult your doctor. Absolutely do not take SAMe when you are already taking drugs for bipolar depression, obsessive compulsive disorder, or addictive tendencies, as it has been known to worsen symptoms.